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The metabolism of Estradiol can be decreased when combined with Posaconazole. The metabolism of Leflunomide can be decreased when combined with Simeprevir. The therapeutic efficacy of Candicidin can be increased when used in combination with Amiodarone. Skin and Appendages Disorders: Pruritus, rash and urticaria. The metabolism of Conjugated estrogens can be decreased when combined with Atomoxetine. Affinity and selectivity of beta-adrenoceptor antagonists in vitro".