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Caution with drugs that lower seizure threshold (eg, theophylline, antidiabetics, anorectics, CNS stimulants, systemic steroids, tricyclic antidepressants, antipsychotics) or factors that lower seizure threshold (eg, opiate or cocaine addiction, excessive use of alcohol or sedatives). Treprostinil may increase the QTc-prolonging activities of Clozapine. It is recommended that the height of children receiving prolonged treatment with inhaleraled corticosteroid is regularly monitored. Do not break, chew, or cut a lansoprazole orally disintegrating tablet, and do not swallow it whole. Pioglitazone, one of the medicines in DUETACT, can cause your body to keep extra fluid (fluid retention), which leads to swelling (edema) and weight gain. Duphalac should be administered with care to patients who are intolerant to lactose (see section 6.